Below you will find representative studies - including many by the Optics Division of the MGH-Martinos Center - in several of the major application areas of near-infrared spectroscopy and diffuse optical tomography. TechEn CW6 systems were used for all of the studies listed here.

Brain Mapping

Medvedev, A.V. (2014). “Does the Resting State Connectivity Have Hemispheric Asymmetry? a Near-Infrared Spectroscopy Study.” NeuroImage 85 Pt 1: 400–407.

Niu, H. and He, Y. (2014). “Resting-State Functional Brain Connectivity: Lessons From Functional Near-Infrared Spectroscopy.” The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry 20 (2): 173–88.

Karim, H.T., Fuhrman, S.I, Furman, J.M. and Huppert, T.J. (2013). “Neuroimaging to Detect Cortical Projection of Vestibular Response to Caloric Stimulation in Young and Older Adults Using Functional Near-Infrared Spectroscopy (fNIRS).” NeuroImage 76: 1–10.

Karim, H., Fuhrman, S.I., Sparto, P., Furman, J. and Huppert, T. (2013). “Functional Brain Imaging of Multi-Sensory Vestibular Processing During Computerized Dynamic Posturography Using Near-Infrared Spectroscopy.” NeuroImage 74: 318–25.

Khan, B., Hodics, T., Hervey, N., Kondraske, G., Stowe, A.M. and Alexandrakis, G. (2013). “Functional Near-Infrared Spectroscopy Maps Cortical Plasticity Underlying Altered Motor Performance Induced by Transcranial Direct Current Stimulation.” Journal of Biomedical Optics 18 (11): 116003

Niu, H., Li, Z., Liao, X., Wang, J., Zhao, T., Shu, N., Zhao, X. and He, Y. (2013). “Test-Retest Reliability of Graph Metrics in Functional Brain Networks: a Resting-State fNIRS Study.” PloS One 8 (9): e72425.

Schytz, H.W., Barlose, M., Guo, S., Selb, J., Caparso, A., Jensen, R. and Ashina, M. (2013). "Experimental activation of the sphenopalatine ganglion provokes cluster-like attacks in humans." Cephalalgia.

Ferrari, M. and Quaresima, V. (2012). "A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application." Neuroimage 63(2): 921-935. (Review)

Gagnon, C., Desjardins-Crepeau, L., Tournier, I., Desjardins, M., Lesage, F., Greenwood, C.E. and Bherer, L. (2012). “Near-Infrared Imaging of the Effects of Glucose Ingestion and Regulation on Prefrontal Activation During Dual-Task Execution in Healthy Fasting Older Adults.” Behavioural Brain Research 232 (1): 137–47.

Huppert, T., Schmidt, B., Beluk, N., Furman, J., and Sparto, P. (2012). “Measurement of Brain Activation During an Upright Stepping Reaction Task Using Functional Near-Infrared Spectroscopy..” Human Brain Mapping.

Kahlaoui, K., Di Sante, G., Barbeau, J., Maheux, M., Lesage, F., Ska, B., and Joanette, Y. (2012). “Contribution of NIRS to the Study of Prefrontal Cortex for Verbal Fluency in Aging.” Brain and Language 121 (2): 164–73.

Niu, H., Wang, J., Zhao, T., Shu, N. and He, Y. (2012). "Revealing Topological Organization of Human Brain Functional Networks with Resting-State Functional near Infrared Spectroscopy." PLoS One 7(9): e45771.

Quaresima, V., Bisconti, S. and Ferrari, M. (2012). “A Brief Review on the Use of Functional Near-Infrared Spectroscopy (fNIRS) for Language Imaging Studies in Human Newborns and Adults.” Brain and Language 121 (2): 79–89.

Scherer, L.C., Fonseca, R.P., Amiri, M., Adrover-Roig, D., Marcotte, K., Giroux, F., Senhadji, N., Benali, H., Lesage, F. and Ansaldo, A.I. (2012). “Syntactic Processing in Bilinguals: an fNIRS Study.” Brain and Language 121 (2): 144–51.

Yucel, M.A., Huppert, T.J., Boas, D.A. and Gagnon, L. (2012). "Calibrating the BOLD signal during a motor task using an extended fusion model incorporating DOT, BOLD and ASL data." Neuroimage 61(4): 1268-1276.

Chen, H.C., Vaid, J., Boas, D.A. and Bortfeld, H. (2011). "Examining the phonological neighborhood density effect using near infrared spectroscopy." Hum Brain Mapp 32(9): 1363-1370.

Niu, H., Khadka, S., Tian, F., Lin, Z.-J., Lu, C., Zhu, C. and Liu, H. (2011). “Resting-State Functional Connectivity Assessed with Two Diffuse Optical Tomographic Systems.” Journal of Biomedical Optics 16 (4): 046006.

Custo, A., Boas, D.A., Tsuzuki, D., Dan, I., Mesquita, R., Fischl, B., Grimson, W.E. and Wells, W., 3rd (2010). "Anatomical atlas-guided diffuse optical tomography of brain activation." Neuroimage 49(1): 561-567.

Mesquita, R.C., Franceschini, M.A. and Boas, D.A. (2010). "Resting state functional connectivity of the whole head with near-infrared spectroscopy." Biomed Opt Exp 1(1): 324-336.

Abdelnour, A.F. and Huppert, T. (2009). “Real-Time Imaging of Human Brain Function by Near-Infrared Spectroscopy Using an Adaptive General Linear Model.” NeuroImage 46 (1): 133–43.

Becerra, L., Harris, W., Grant, M., George, E., Boas, D. and Borsook, D. (2009). "Diffuse optical tomography activation in the somatosensory cortex: specific activation by painful vs. non-painful thermal stimuli." PLoS One 4(11): e8016.

Hull, R., Bortfeld, H. and Koons, S. (2009). "Near-infrared spectroscopy and cortical responses to speech production." The Open Neuroimaging Journal 3: 26-30.

Becerra, L., Harris, W., Joseph, D., Huppert, T., Boas, D.A. and Borsook, D. (2008). “Diffuse Optical Tomography of Pain and Tactile Stimulation: Activation in Cortical Sensory and Emotional Systems.” NeuroImage 41 (2): 252–59.

Chen, H.C., Vaid, J., Bortfeld, H. and Boas, D.A. (2008). "Optical imaging of phonological processing in two distinct orthographies." Exp Brain Res 184(3): 427-33.

Grignon, S., Forget, K., Durand, M. and Huppert, T. (2008). “Increased Left Prefrontal Activation During Staring/Mutism Episodes in a Patient with Resistant Catatonic Schizophrenia: a Near Infrared Spectroscopy Study.” Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology 21 (1): 41–45.

Franceschini, M.A., Joseph, D.K., Huppert, T.J., Diamond, S.G. and Boas, D.A. (2006). "Diffuse optical imaging of the whole head." Journal Biomed Optics 11(5): 054007.

Huppert, T.J., Hoge, R.D., Diamond, S.G., Franceschini, M.A. and Boas, D.A. (2006). "A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans." Neuroimage 29(2): 368-82.

Joseph, D.K., Huppert, T.J., Franceschini, M.A. and Boas, D.A. (2006). "Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging." Appl Opt 45(31): 8142-51.

Selb, J., Joseph, D.K. and Boas, D.A. (2006). "Time-gated optical system for depth-resolved functional brain imaging." Journal Biomed Optics 11(4): 044008.

Culver, J.P., Siegel, A.M., Franceschini, M.A., Mandeville, J.B. and Boas, D.A. (2005). "Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin." Neuroimage 27(4): 947-59.

Hoge, R.D., Franceschini, M.A., Covolan, R.J., Huppert, T., Mandeville, J.B. and Boas, D.A. (2005). "Simultaneous recording of task-induced changes in blood oxygenation, volume, and flow using diffuse optical imaging and arterial spin-labeling MRI." Neuroimage 25(3): 701-7.

Selb, J., Stott, J.J., Franceschini, M.A., Sorensen, A.G. and Boas, D.A. (2005). "Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation." J Biomed Opt 10(1): 11013.

Franceschini, M.A. and Boas, D.A. (2004). “Noninvasive Measurement of Neuronal Activity with Near-Infrared Optical Imaging.” NeuroImage 21 (1): 372–86.

Breast Imaging

Carp, S.A., Sajjadi, A.Y., Wanyo, C.M., Fang, Q., Specht, M.C., Schapira, L., Moy, B., Bardia, A., Boas, D.A. and Isakoff, S.J. (2013). “Hemodynamic Signature of Breast Cancer Under Fractional Mammographic Compression Using a Dynamic Diffuse Optical Tomography System.” Biomedical Optics Express 4 (12): 2911–24.

Fang, Q., Selb, J., Carp, S.A., Boverman, G., Miller, E.L., Brooks, D.H., Moore, R.H., Kopans, D.B. and Boas, D.A. (2011). "Combined optical and X-ray tomosynthesis breast imaging." Radiology 258(1): 89-97.

Fang, Q., Moore, R.H., Kopans, D.B. and Boas, D.A. (2010) "Compositional-prior-guided Image Reconstruction Algorithm for Multi-modality Imaging." Biomed Opt Express 1(1): 223-235.

Fang, Q., Carp, S.A., Selb, J., Boverman, G., Zhang, Q., Kopans, D.B., Moore, R.H., Miller, E.L., Brooks, D.H. and Boas, D.A. (2009). "Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression." IEEE Trans Med Imaging 28(1): 30-42.

Carp, S.A., Selb, J., Fang, Q., Moore, R., Kopans, D.B., Rafferty, E. and Boas, D.A. (2008). "Dynamic functional and mechanical response of breast tissue to compression." Opt Express 16(20): 16064-78.

Boverman, G., Fang, Q., Carp, S.A., Miller, E.L., Brooks, D.H., Selb, J., Moore, R.H., Kopans, D.B. and Boas, D.A. (2007). "Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography." Phys Med Biol 52(12): 3619-41.

Carp, S.A., Kauffman, T., Fang, Q., Rafferty, E., Moore, R., Kopans, D. and Boas, D. (2006). "Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements." Journal Biomed Optics 11(6): 064016.

Boverman, G., Miller, E.L., Li, A., Zhang, Q., Chaves, T., Brooks, D.H. and Boas, D.A. (2005). "Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information." Phys Med Biol 50(17): 3941-56.

Zhang, Q., Brukilacchio, T.J., Li, A., Stott, J.J., Chaves, T., Hillman, E., Wu, T., Chorlton, M., Rafferty, E., Moore, R.H., Kopans, D.B. and Boas, D.A. (2005). "Coregistered tomographic x-ray and optical breast imaging: initial results." J Biomed Opt 10(2): 024033.

Other Multimodal Imaging

Cooper, R.J., Gagnon, L., Goldenholz, D.M., Boas, D.A. and Greve, D.N. (2012). “The Utility of Near-Infrared Spectroscopy in the Regression of Low-Frequency Physiological Noise From Functional Magnetic Resonance Imaging Data.” NeuroImage 59 (4): 3128–38.

Leamy, D.J. and Ward, T.E. (2010). “A Novel Co-Locational and Concurrent fNIRS/EEG Measurement System: Design and Initial Results.” Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference 2010: 4230–33.

Huppert, T.J., Allen, M.S., Diamond, S.G. and Boas, D.A. (2009). “Estimating Cerebral Oxygen Metabolism From fMRI with a Dynamic Multicompartment Windkessel Model.” Human Brain Mapping 30 (5): 1548–67.

Kozel, F.A., Tian, F., Dhamne, S., Croarkin, P.E., McClintock, S.M., Elliott, A., Mapes, K.S., Husain, M.M. and Liu, H. (2009). “Using Simultaneous Repetitive Transcranial Magnetic Stimulation/Functional Near Infrared Spectroscopy (rTMS/fNIRS) to Measure Brain Activation and Connectivity.” NeuroImage 47 (4): 1177–84.

Epilepsy Research

Machado, A., Lina, J.M., Tremblay, J., Lassonde, M., Nguyen, D.K., Lesage, F. and Grova, C. (2011). "Detection of hemodynamic responses to epileptic activity using simultaneous Electro-EncephaloGraphy (EEG)/Near Infra Red Spectroscopy (NIRS) acquisitions." Neuroimage 56(1): 114-125.

Cerebral Palsy Research

Khan, B., Tian, F., Behbehani, K., Romero, M.I., Delgado, M.R., Clegg, N.J., Smith, L., Reid, D., Liu, H. and Alexandrakis, G. (2010). "Identification of abnormal motor cortex activation patterns in children with cerebral palsy by functional near-infrared spectroscopy." J Biomed Opt 15(3): 036008.

Tian, F., Delgado, M.R., Dhamne, S.C., Khan, B., Alexandrakis, G., Romero, M.I., Smith, L., Reid, D., Clegg, N.J. and Liu, H. (2010). “Quantification of Functional Near Infrared Spectroscopy to Assess Cortical Reorganization in Children with Cerebral Palsy.” Optics Express 18 (25): 25973–86.

Studies of Cognitive Development

Buss, A.T., Fox, N., Boas, D.A. and Spencer, J.P. (2014). “Probing the Early Development of Visual Working Memory Capacity with Functional Near-Infrared Spectroscopy.” NeuroImage 85 Pt 1: 314–25.

Perlman, S.B., Luna, B., Hein, T.C. and Huppert, T.J. (2014). “fNIRS Evidence of Prefrontal Regulation of Frustration in Early Childhood.” NeuroImage 85 Pt 1: 326–34.

Roche-Labarbe, N., Fenoglio, A., Radhakrishnan, H., Kocienski-Filip, M., Carp, S.A., Dubb, J., Boas, D.A., Grant, P.E. and Franceschini, M.A. (2014). “Somatosensory Evoked Changes in Cerebral Oxygen Consumption Measured Non-Invasively in Premature Neonates.” NeuroImage 85 Pt 1: 279–86. doi:10.1016/j.neuroimage.2013.01.035.

Wilcox, T., Hirshkowitz, A., Hawkins, L. and Boas, D.A. (2014). “The Effect of Color Priming on Infant Brain and Behavio..” NeuroImage 85 Pt 1: 302–13.

Buss, A.T., Fox, N., Boas, D.A. and Spencer, J.P. (2013). "Probing the early development of visual working memory capacity with functional near-infrared spectroscopy." Neuroimage.

Wilcox, T., Stubbs, J., Hirshkowitz, A. and Boas, D.A. (2012). "Functional activation of the infant cortex during object processing." Neuroimage 62(3): 1833-1840.

Zimmermann, B.B., Roche-Labarbe, N., Surova, A., Boas, D.A., Wolf, M., Grant, P.E. and Franceschini, M.A. (2012). “The Confounding Effect of Systemic Physiology on the Hemodynamic Response in Newborns.” Advances in Experimental Medicine and Biology 737: 103–9.

Hyde, D.C., Boas, D.A., Blair, C. and Carey, S. (2010). "Near-infrared spectroscopy shows right parietal specialization for number in pre-verbal infants." Neuroimage 53(2): 647-652.

Sevy, A., Bortfeld, H., Huppert, T., Beauchamp, M., Tonini R. and Oghalai J. (2010). "Neuroimaging with near-infrared spectroscopy demonstrates speech-evoked activity in the auditory cortex of deaf children following cochlear implantation." Hearing Research 270: 39-47.

Wilcox, T., Haslup, J.A. and Boas, D.A. (2010). "Dissociation of processing of featural and spatiotemporal information in the infant cortex." Neuroimage. 53(4):1256-63.

Bortfeld, H., Fava, E. and Boas, D.A. (2009). "Identifying cortical lateralization of speech processing in infants using near-infrared spectroscopy." Dev Neuropsychol 34(1): 52-65

Wilcox, T., Bortfeld, H., Woods, R., Wruck, E., Armstrong, J. and Boas, D. (2009). "Hemodynamic changes in the infant cortex during the processing of featural and spatiotemporal information." Neuropsychologia 47: 657-662.

Wilcox, T., Bortfeld, H., Woods, R., Wruck, E. and Boas, D.A. (2008). "Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological exploration." Dev Sci 11(3): 361-70.

Bortfeld, H., Wruck, E. and Boas, D.A. (2007). "Assessing infants' cortical response to speech using near-infrared spectroscopy." Neuroimage 34(1): 407-15.

Wilcox, T., Bortfeld, H., Woods, R., Wruck, E. and Boas, D.A. (2005). "Using near-infrared spectroscopy to assess neural activation during object processing in infants." J Biomed Opt 10(1): 11010.

Technology Development

Gagnon, L., Yucel, M.A., Boas, D.A. and Cooper, R.J. (2014). “Further Improvement in Reducing Superficial Contamination in NIRS Using Double Short Separation Measurements.” NeuroImage 85 Pt 1: 127–35.

Scholkmann, F., Kleiser, S., Metz, A.J., Zimmermann, R., Pavia, J.M., Wolf, U. and Wolf, M.( 2014). “A Review on Continuous Wave Functional Near-Infrared Spectroscopy and Imaging Instrumentation and Methodology..” NeuroImage 85 Pt 1: 6–27.

Tian, F. and Liu, H. (2014). “Depth-Compensated Diffuse Optical Tomography Enhanced by General Linear Model Analysis and an Anatomical Atlas of Human Head..” NeuroImage 85 Pt 1: 166–80.

Khan, B., Wildey, C., Francis, R., Tian, F., Delgado, M.R., Liu, H., Macfarlane, D. and Alexandrakis, G. (2012). "Improving optical contact for functional nearinfrared brain spectroscopy and imaging with brush optodes." Biomed Opt Express 3(5): 878-98.

Tian, F., Kozel, F.A., Yennu, A., Croarkin, P.E., McClintock, S.M., Mapes, K.S., Husain, M.M. and Liu, H. (2012). "Test-retest assessment of cortical activation induced by repetitive transcranial magnetic stimulation with brain atlas-guided optical topography." J Biomed Opt 17(11): 116020.

Sweeney, K.T., Ayaz, H., Ward, T.E., Izzetoglu, M.,McLoone, S.F. and Onaral, B. (2011). “A Methodology for Validating Artifact Removal Techniques for fNIRS.” Conference Proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference 2011: 4943–46.

Huppert, T.J., Diamond, S.G., Franceschini, M.A. and Boas, D.A. (2009). “HomER: a Review of Time-Series Analysis Methods for Near-Infrared Spectroscopy of the Brain.” Applied Optics 48 (10): D280–98.

Muehlschlegel, S., Selb, J., Patel, M., Diamond, S.G., Franceschini, M.A., Sorensen, A.G., Boas, D.A. and Schwamm, L.H. (2009). “Feasibility of NIRS in the Neurointensive Care Unit: a Pilot Study in Stroke Using Physiological Oscillations..” Neurocritical Care 11 (2): 288–95.