Publications

Below you will find representative publications in some of the major application areas of near-infrared spectroscopy and diffuse optical tomography.

For recent MGH publications, using NIRS and CW systems
http://www.nmr.mgh.harvard.edu/PMI/publications.htm

Brain Mapping

Franceschini, M.A., Joseph, D.K., Huppert, T.J., Diamond, S.G. and Boas, D.A. (2006). "Diffuse optical imaging of the whole head." Journal Biomed Optics 11(5): 054007.

Huppert, T.J., Hoge, R.D., Diamond, S.G., Franceschini, M.A. and Boas, D.A. (2006). "A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans." Neuroimage 29(2): 368-82.

Joseph, D.K., Huppert, T.J., Franceschini, M.A. and Boas, D.A. (2006). "Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging." Appl Opt 45(31): 8142-51.

Selb, J., Joseph, D.K. and Boas, D.A. (2006). "Time-gated optical system for depth-resolved functional brain imaging." Journal Biomed Optics 11(4): 044008.

Culver, J.P., Siegel, A.M., Franceschini, M.A., Mandeville, J.B. and Boas, D.A. (2005). "Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin." Neuroimage 27(4): 947-59.

Hoge, R.D., Franceschini, M.A., Covolan, R.J., Huppert, T., Mandeville, J.B. and Boas, D.A. (2005). "Simultaneous recording of task-induced changes in blood oxygenation, volume, and flow using diffuse optical imaging and arterial spin-labeling MRI." Neuroimage 25(3): 701-7.

Selb, J., Stott, J.J., Franceschini, M.A., Sorensen, A.G. and Boas, D.A. (2005). "Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation." J Biomed Opt 10(1): 11013.

Neonatal Monitoring

Bortfeld, H., Wruck, E. and Boas, D.A. (2007). "Assessing infants' cortical response to speech using near-infrared spectroscopy." Neuroimage 34(1): 407-15.

Franceschini, M.A., Thaker, S., Themelis, G., Krishnamoorthy, K.K., Bortfeld, H., Diamond, S.G., Boas, D.A., Arvin, K. and Grant, P.E. (2007). "Assessment of infant brain development with frequency-domain near-infrared spectroscopy." Pediatr Res 61(5 Pt 1): 546-51.

Wilcox, T., Bortfeld, H., Woods, R., Wruck, E. and Boas, D.A. (2005). "Using near-infrared spectroscopy to assess neural activation during object processing in infants." J Biomed Opt 10(1): 11010.

Breast Imaging

Boverman, G., Fang, Q., Carp, S.A., Miller, E.L., Brooks, D.H., Selb, J., Moore, R.H., Kopans, D.B. and Boas, D.A. (2007). "Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography." Phys Med Biol 52(12): 3619-41.

Carp, S.A., Kauffman, T., Fang, Q., Rafferty, E., Moore, R., Kopans, D. and Boas, D. (2006). "Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements." Journal Biomed Optics 11(6): 064016.

Zhang, Q., Brukilacchio, T.J., Li, A., Stott, J.J., Chaves, T., Hillman, E., Wu, T., Chorlton, M., Rafferty, E., Moore, R.H., Kopans, D.B. and Boas, D.A. (2005). "Coregistered tomographic x-ray and optical breast imaging: initial results." J Biomed Opt 10(2): 024033.

Boverman, G., Miller, E.L., Li, A., Zhang, Q., Chaves, T., Brooks, D.H. and Boas, D.A. (2005). "Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information." Phys Med Biol 50(17): 3941-56.

Zhang, Q., Brukilacchio, T.J., Li, A., Stott, J.J., Chaves, T., Hillman, E., Wu, T., Chorlton, M., Rafferty, E., Moore, R.H., Kopans, D.B. and Boas, D.A. (2005). "Coregistered tomographic x-ray and optical breast imaging: initial results." J Biomed Opt 10(2): 024033.